Current contact information

Jin-Xin BEI , Ph.D.

** Distinguished Professor,

- Principal Investigator, Professor and Vice director, Department of Experimental Research, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China

- Joint Professor, Division of Medical Oncology, National Cancer Center of Singapore, Singapore

- Honorary Professor, Department of Medical Oncology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong

Tel: +86 20 87343189; +86 20 39336779

E-mail: beijx@sysucc.org.cn

 

Job opportunity

We are hiring co-PIs, postdoc, students, and technicians with respective qualifications. Please contact us via the email above.

 

 

Biography

Dr. Bei obtained his B.S. and Ph.D. degrees from Sun Yat-sen University, Guangzhou, China. Right after that the joined Sun Yat-sen University Cancer Center (SYSUCC) as a postdoc and Genome Institute of Singapore (GIS) as visiting research fellow. He returned to SYSUCC after years of working as research scientist at GIS. His major research interest is to dissect genetic predispositions, acquired alterations, environmental factors (intrinsic and extrinsic) contributing to cancer heterogeneity, as well as the underlying mechanisms. He has published more than 130 scientific papers including those in prestigious journals such as Cell, Nat Genet, Lancet Oncol, etc. He has track-records in organizing large international collaborations. 

Research Interest

Cancer is a complex systemic disease driven by genetic predispositions and acquired alterations arising from factors such as pathogen infections, environmental exposures, and stress. These elements collectively create a sophisticated niche that fosters tumor initiation, progression, therapeutic resistance, and relapse. Our research focuses on dissecting the interplay between germline variations, acquired changes in host and/or pathogens, and the tumor microenvironment across multiple dimensions, aiming to elucidate the intricate mechanisms underlying cancer development and evolution. 

His team primarily study Epstein-Barr Virus (EBV)-related malignancies, such as Nasopharyngeal Carcinoma (NPC), Natural Killer/T cell lymphoma (NKTCL), and gastric cancer. These cancers are uniquely significant due to their strong associations with EBV and their high prevalence in Southern China. Leveraging these models, our team has established robust multi-omics data generation and analysis platforms. These platforms integrate genome-wide genetic data, transcriptomics, and epigenomics, analyzed at both bulk tissue/cell and single-cell levels. Coupled with clinical and follow-up data, we conduct association and mapping studies to identify key genes, pathways, and cellular networks that influence cancer risk, diagnostics, therapeutic response, prognosis, and patient survival.

A vital component of our strategy is fostering international collaborations, which enable us to integrate diverse expertise and resources from global partners. Through these collaborative efforts, we aim to advance our understanding of cancer biology and evolution, ultimately contributing to the development of more effective prevention and treatment strategies for this challenging disease.

Academic and research positions

2013-Present, Professor and Principal Investigator, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, China

2025-Present, Honorary Professor, Department of Clinical Oncology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China

2023-Present, Adjunct Professor, Liaoning Cancer Hospital & Institute, Dalian University of Technology, Liao Ning, China

2021-Present, Adjunct Professor, Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China

2021-Present, Joint Professor, Division of Medical Oncology, National Cancer Center of Singapore, Singapore

2016-2022, Director, core facility of biomedical research, Center for Precision Medicine, Sun Yat-sen University, China

2014-2018, Adjunct Research Scientist, Human Genetics, Genome Institute of Singapore, Singapore

2011-2014, Research Scientist, Human Genetics, Genome Institute of Singapore, Singapore

2010-2013, Associate Professor, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center

2008-2010, Visiting Research Fellow, Human Genetics, Genome Institute of Singapore, Singapore

2007-2010, Postdoctoral Fellow, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, China

Publication records 

He has published more than 130 SCI papers, including those being corresponding or first authorship in Cell, Lancet Oncology (2), Nature Genetics (3), J Clin Invest, Advanced Sciences (2), Nature Communications (2), etc. 

a. 10 most representative publications (*Correspondence; #equal contribution)

  1. Zeng Y, Luo CL, Lin GW, Li F, Bai X, Ko JM, Xiong L, Liu Y, He S, Jiang JX, Yan WX, Ong EHW, Li Z, Zhou YQ, Zhou YH, Xu AY, Liu SQ, Guo YM, Chen JR, Cheng XX, Cao YL, Yu X, Wu B, Wei PP, Ruan ZH, Chen QY, Tang LQ, McKay JD, Jia WH, Mai HQ, Lim ST, Liu JJ, Lin DX, Khor CC, Chua MLK#, Ji M#, Lung ML#, Zeng YX#, & Bei JX#*. Whole-exome sequencing association study reveals genetic effects on tumor microenvironment components in nasopharyngeal carcinoma. J Clin Invest 135, e182768 (2025). [5Y-IF=14.6]

  2. Liu Y, Ye SY, He S, Chi DM, Wang XZ, Wen YF, Ma D, Nie RC, Xiang P, Zhou Y, Ruan ZH, Peng RJ, Luo CL, Wei PP, Lin GW, Zheng J, Cui Q, Cai MY, Yun JP, Dong J, Mai HQ, Xia X, & Bei JX*. Single-Cell and Spatial Transcriptome Analyses Reveal Tertiary Lymphoid Structures Linked to Tumour Progression and Immunotherapy Response in Nasopharyngeal Carcinoma. Nat Commun 15, 7713 (2024). [5Y-IF=16.1]

  3. Li YQ, Luo CL, Jiang JX, He S, Liu Y, Yan WX, Xia Y, Cui Q, Huang Y, Lim JQ, Huang D, Hussein IN, Gao Y, Lin GW, Ling YH, Ma D, Zhang YT, Chan JY, Wei PP, Wang XX, Cheng CL, Xiong J, Zhao WL, Ong CK, Lim ST, Huang HQ, Peng RJ#* & Bei JX#*. Single-Cell Analysis Reveals Malignant Cells Reshape the Cellular Landscape and Foster an Immunosuppressive Microenvironment of Extranodal NK/T-Cell Lymphoma. Adv Sci 10, e2303913 (2023). [5Y-IF=16.3]

  4. Ren X, Wen W, Fan X, Hou W, Su B, Cai P, Li J, Liu Y, Tang F, Zhang F, Yang Y, He J, Ma W, He J, Wang P, Cao Q, Chen F, Chen Y, Cheng X, Deng G, Deng X, Ding W, Feng Y, Gan R, Guo C, Guo W, He S, Jiang C, Liang J, Li YM, Lin J, Ling Y, Liu H, Liu J, Liu N, Liu SQ, Luo M, Ma Q, Song Q, Sun W, Wang G, Wang F, Wang Y, Wen X, Wu Q, Xu G, Xie X, Xiong X, Xing X, Xu H, Yin C, Yu D, Yu K, Yuan J, Zhang B, Zhang P, Zhang T, Zhao J, Zhao P, Zhou J, Zhou W, Zhong S, Zhong X, Zhang S, Zhu L, Zhu P, Zou B, Zou J, Zuo Z, Bai F, Huang X, Zhou P#*, Jiang Q#*, Huang Z#*, Bei JX#*, Wei L#*, Bian XW#*, Liu X#*, Cheng T#*, Li X#*, Zhao P#*, Wang FS#*, Wang H#*, Su B#*, Zhang Z#*, Qu K#*, Wang X#*, Chen J#*, Jin R#*, Zhang Z#*. COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas. Cell 184, 1895 (2021). [5Y-IF=49.0]

  5. Liu Y, He S, Wang XL, Peng W, Chen QY, Chi DM, Chen JR, Han BW, Lin GW, Li YQ, Wang QY, Peng RJ, Wei PP, Guo X, Li B, Xia X, Mai HQ, Hu XD, Zhang Z#*, Zeng YX#* & Bei JX#*. Tumour Heterogeneity and Intercellular Networks of Nasopharyngeal Carcinoma at Single Cell Resolution. Nat Commun 12, 741 (2021). [5Y-IF=16.1]

  6. Luo CL, Xu XC, Liu CJ, He S, Chen JR, Feng YC, Liu SQ, Peng W, Zhou YQ, Liu YX, Wei PP, Li B, Mai HQ, Xia XJ & Bei JX*. RBFOX2/GOLIM4 Splicing Axis Activates Vesicular Transport Pathway to Promote Nasopharyngeal Carcinogenesis. Adv Sci8, e2004852 (2021).[5Y-IF=16.3]

  7. He S, Wang LH, Liu Y, Li YQ, Chen HT, Xu JH, Peng W, Lin GW, Wei PP, Li B, Xia X, Wang D, Bei JX#*, He X#*, Guo Z#*. Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs. Genome Biol21, 294 (2020). [5Y-IF=16.5]

  8. Lin GW, Xu C, Chen K, Huang HQ, Chen J, Song B, Chan JKC, Li W, Liu W, Shih LY, Chuang WY, Kim WS, Tan W, Peng RJ, Laurensia Y, Cheah DMZ, Huang D, Cheng CL, Su YJ, Tan SY, Ng SB, Tang TPL, Han K, Wang VY, Jia WH, Pei Z, Li YJ, Gao S, Shi Y, Hu Z, Zhang F, Zhang B, Zeng YX, Shen H, He L, Ong CK, Lim ST, Chanock S, Kwong YL#, Lin D#, Rothman N#, Khor CC#, Lan Q# & Bei JX#*. Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study in multiple populations. Lancet Oncol21, 306-316 (2020). [5Y-IF=42.2]

  9. Li Z, Xia Y, Feng LN, Chen JR, Li HM, Cui J, Cai QQ, Sim KS, Nairismagi ML, Laurensia Y, Meah WY, Liu WS, Guo YM, Chen LZ, Feng QS, Pang CP, Chen LJ, Chew SH, Ebstein RP, Foo JN, Liu J, Ha J, Khoo LP, Chin ST, Zeng YX, Aung T, Chowbay B, Diong CP, Zhang F, Liu YH, Tang T, Tao M, Quek R, Mohamad F, Tan SY, Teh BT, Ng SB, Chng WJ, Ong CK, Okada Y, Raychaudhuri S, Lim ST, Tan W#, Peng RJ#, Khor CC# & Bei JX#*. Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study. Lancet Oncol17, 1240-7 (2016). [5Y-IF=42.2]

  10. Bei JX#, Li Y#, Jia WH, Feng BJ, Zhou G, Chen LZ, Feng QS, Low HQ, Zhang H, He F, Tai ES, Kang T, Liu ET, Liu J & Zeng YX. A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Nat Genet 42,599 (2010).[5Y-IF=36.6]

 

b. Full list of publications

For the full list of publications, please refer to the hyperlink below.

https://pubmed.ncbi.nlm.nih.gov/?term=bei+jin-xin&sort=date&size=200

Invited Presentations [10 selected]

  1. June 2-7, 2024, Gordon Research Conference on Nasopharyngeal Carcinoma, Les Diablerets, Switzerland

  2. Nov 21-22, 2019, International Conference of the Genetics Society of Korea (ICGSK), 2019, Gyeonggi-do, Korea

  3. Jul 24-28, 2019, the 17th SCBA (Society of Chinese Bioscientists in America) international Symposium, Kunming, China [section chairman]

  4. Jun 24-29, 2018, Gordon Research Conference on Nasopharyngeal Carcinoma, Hong Kong [Discussion Leader]

  5. Jun 26 - Jul 1, 2016, Nasopharyngeal Carcinoma, Gordan Research Conference, Hong Kong

  6. Jun 3-6, 2015, the 7th Biannual Nasopharyngeal Carcinoma Meeting, Yogyakarta, Indonesia

  7. Nov 1-4, 2014, Advances in Nasopharyngeal Carcinoma Studies, Hong Kong

  8. Oct 31, 2014, Advances in EBV and Nasopharyngeal Carcinoma Research, the 10th Asia Pacific Multidisciplinary Meeting for Cancer Research, Hong Kong

  9. Jun 20-22, 2013, the 6th International Symposium on Nasopharyngeal Carcinoma 2013 (NPC 2013), Istanbul, Turkey [co-chairman]

  10. May 31 - Jun 3, 2011, Global Academic Programs (GAP) 2011 Conference, Houston, USA

Grants (10 selected)

  1. The “Biomacromolecules and microbiome" key project, the National Key R&D Program of China, 2021/12-2026/12, RMB 7.02 million [PI]

  2. The key project of the National Natural Science Foundation of China (NSFC), 2022/01-2026/12, RMB 2.90 million [PI]

  3. The international (regional) cooperation and exchange programs of NSFC, 2023/01-2025/12, RMB 1.70 million [PI]

  4. The general project of NSFC, 2016/01-2019/12, RMB 0.57 million [PI]

  5. The key project of the the Sci-Tech Project Foundation of Guangzhou city, 2017/05-2020/04, RMB 3 million [Co-PI]

  6. The “Precision medicine” key project, the National Key R&D Program of China, 2016/07-2018/12, RMB 1.28 million [Major collaborator]

  7. The international (regional) cooperation and exchange programs of NSFC, NSFC-NRF (China-Singapore), 2017/01-2019/12, RMB 1.65 million [PI]

  8. The general project of NSFC, 2016/01-2019/12, RMB 0.57 million [PI]

  9. The Young Scholar Fund of NSFC, 2013/01-2015/12, RMB 1million [PI]

  10. The cancer genomics project, the National High-tech R&D Program of China (863 Program), 2012/01-2015/12, RMB 13.44 million [PI]

Awards

  1. The second prize of the National Natural Science Award (Bei Jin-Xin as the 3rd member), 2016

  2. Distinguished Professorship, Chang Jiang Scholars Program, the Ministry of Education, 2019

  3. The 2nd Selection of China Cancer Young Scientist Award, China Anti-Cancer Association, 2018

  4. Innovation and Application of Individualized Diagnosis and Treatment Strategy for non-Hodgkin's Lymphoma, Guangdong Provincial People's Government, Science and Technology Progress, Provincial First Prize (Bei Jin-Xin as the 5th contributor), 2018

  5. Innovation and application of individualized diagnosis and treatment strategies for non-Hodgkin lymphoma, Chinese Medical Association, Science and Technology Progress (Bei Jin-Xin as the 5th contributor), 2018 

  6. Outstanding Young Medical Talents of Guangdong Province, Guangdong Provincial Health and Family Planning Commission, Guangdong Provincial Health and Family Planning Commission, 2018

  7. Young Scholar, Chang Jiang Scholars Program, the Ministry of Education, 2015

  8. National Program for Support of Top-Notch Young Professionals, 2015

  9. Hundred, Thousand, Ten Thousand Talents, Project Special Support Program of Guangdong, 2014

  10. Program for New Century Excellent Talents in University, the Ministry of Education, 2011

Professional Affiliations

a. Organizations

2023 – Present, member of Council, Chinese Society for Cell Biology, China

2023 – Present, Honorary Consultants, Greater Bay Area Medical Professional Development Association, Hong Kong, China

2021 – Present, Honorary Consultants, Hong Kong Association of Psycology, Hong Kong, China

2021 – Present, Chairman, Single cell Technology Branch, Guangdong Precision Medicine Application Association, China

2021, Guideline committee member, the "Biological and Informatics Integration (BT and IT integration)" key special project, the National Key R&D Program of China plan, China

2019 – Present, member of the Youth Committee, the Chinese Anti-Cancer Association, China

2018 – Present, Vice Chairman, Medical Genetics Committee of the Association of Medicine in Guangdong, China

2017 – Present, Standing Committee Member of the Asia-Pacific Association of Medicine and Bio-Immunology

2016 – 2021, Vice Chairmen, the Youth Committee of Tumor Etiology Branch, the Chinese Anti-Cancer Association, China

2016 – Present, Founder, International Natural Killer T Cell Lymphoma (NKTCL) Working Group

2015, member of the Scientific International Committee, the7th Biannual Nasopharyngeal Carcinoma

2013 – Present, member of the Youth Committee, the Genetics Society of China

2014 – Present, member of the Youth Committee, Chinese Society for Cell Biology, China

2012 – Present, member of Chinese Cancer Genome Consortium, China

2012 – Present, member of International Cancer Genome Consortium (NPC)

2012 – Present, Founder, International Nasopharyngeal Carcinoma (NPC) Working Group

Editorial Boards

2023 – Present, Editorial Board Member, Journal of Cancer Metastasis and Treatment

2020 – Present, Editorial Board member, Chinese Journal of Cell Biology

2020 – Present, Editor, Journal of Genetics and Genomics

2017 – 2022, Associate Editor, Journal of Gene Medicine

2017 – Present, Editorial Board member, Annals of Nasopharynx Cancer

2012 – Present, Managing Editor, Cancer Communications (previously known as Chinese Journal of Cancer)

 

c. Peer Review 

He has provided peer reviews for Nature, Nature Microbiology, STTT, Blood, CMAJ, Adv Sci, Nuc Aci Res, Nat Commun, etc.

Selected Patents Granted 

  1. Bei JX, Ng CK, Lim JQ, Lim ST, Li YQ. A set of nk/t cell lymphoma prognosis-related genes, genomic prognostic model and use thereof (ZL202210660332.7), 2023-02-28, China. PCT: WO2023240725A1, 2023-12-21

  2. Bei JX, Liu Y, He S. Antibody combination, system and application for detecting nasopharyngeal carcinoma prognosis (ZL202211155726.3),2023-10-20, China

  3. Bei JX, Liu Y, He S. The marker combination, system and application of tertiary lymph structure components for predicting nasopharyngeal carcinoma prognosis, (ZL202211155709.X), 2023-08-25, China

  4. Bei JX, Zeng YX, Guo YM, Feng YC, Chen JR, Wei PP. A SNP marker for tumor prognosis and application thereof (ZL201910240312.2), 2023-03-21, China

  5. Bei JX, Liao W, Zuo XY, Ouyang WH, Wei PP, Ma G. A kind of material, kit and method detected for systemic infection (ZL201710526679.1), 2022-05-03, China

  6. Bei JX, Feng LN, Zuo XY, Liu WS. A kind of kit and method for HLA Genotypings (ZL201510757211.4), 2018-08-28, China